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Mechanism of action of ready-to-use CARDENE® I.V. (nicardipine hydrochloride)

CARDENE I.V. is a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker). It inhibits calcium ions from entering cardiac and vascular smooth muscle cells. The contractile processes of cardiac muscle and vascular smooth muscle depend upon the movement of extracellular calcium ions into these cells through specific ion channels. CARDENE I.V., which is more selective to vascular smooth muscle than cardiac muscle, causes arteries to dilate, decreasing blood pressure.1

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Solely an afterload reducer

Acute hypertensive emergencies may result from an abrupt increase in systemic vascular resistance (SVR).2,3

Ready-to-use CARDENE I.V. and other parenteral antihypertensive agents

Various agents, including nitrovasodilators and beta-blockers, are available for the control of blood pressure in hypertensive emergencies. Each of these agents has distinctive properties and effects on the blood pressure equation. The agent of choice in any particular situation will depend on the clinical presentation.2

The Impact of Select Medications on the Blood Pressure Equation3,5

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